Death or poor prognosis after cardiac surgery Risk Exhaled carbon monoxide levels above 13 ppm were more than 20 times higher in smokers, suggesting heavy smoking and smoke inhalation. This is the finding of a recent study presented at the 2022 ESC Congress.
“The carbon monoxide level in the breath directly affects the amount of carbon monoxide in the breath,” said lead researcher Professor Patrick Henry of the Hospital Larry Boisier in Paris, France “Individuals can inhale deeply or not, either from the beginning to the end, or let the cigarette burn in the ashtray. Finally, where smoking occurs may play a crucial role; smoking in a small, non-smoking area. – A ventilated room may increase carbon monoxide levels compared to smoking outside. ”
The burning of cigarettes produces carbon monoxide, a highly toxic gas that is also present in motor vehicle exhaust, pollution and In a malfunctioning furnace, carbon monoxide replaces oxygen in the blood and can be fatal. Professor Henry said: “Patients with acute cardiac events such as heart attacks have insufficient oxygen in their coronary arteries. We hypothesized that the event could have been more severe if some of the oxygen was replaced by carbon monoxide.
Measured within two hours of admission for all consecutively hospitalized adults over a two-week period in April 2021 Exhaled carbon monoxide Acute cardiac events in 39 Intensive Care Units (ICCUs) in France. A total of 1,379 patients were studied. The mean age was 63 years, and 70% were male. Regarding the reasons for admission, 720 (52%) patients had acute cardiac events Coronary syndrome, acute heart failure in 186 (13%) patients and other acute heart disease in 473 (34%) patients. Median stay in ICCU was 5 days.
Asked about smoking status of patients. One-third of participants (33%) were non-smokers, 39% were ex-smokers, and 27% were active Smokers. Non-smokers and ex-smokers had similar carbon monoxide levels (3.6 and 3.3 ppm, respectively; p=0.12), while active smokers had significantly higher carbon monoxide levels (mean 9.9 ppm; p
We analyzed the association between carbon monoxide levels and the primary outcome of major adverse events in the hospital, which was death, cardiac arrest Resuscitation or cardiogenic shock. Major adverse events occurred during hospitalization in 58 (4.2%) patients. Carbon monoxide levels were significantly associated with major adverse events in active smokers, with an odds ratio of 1.14/ppm, meaning that every increase in carbon monoxide 1 ppm had a 14% higher chance of an event.
Researchers determined 13 ppm was the best threshold for predicting worse outcomes .Smokers with carbon monoxide levels higher than 13 ppm were 23 times more likely to experience major adverse events than those with 13 ppm or lower.Adjusted for factors that may have influenced this relationship, including age, gender, diabetes, smoking status, History of cardiovascular disease, chronic kidney disease, cancer, and reasons for admission. The incidence of major adverse events was similar in smokers with carbon monoxide levels of 13 ppm or less than in non-smokers or former smokers (p=0.65). Nearly 5 One in 19 (19%) active smokers had carbon monoxide levels above 13 ppm compared to less than 2% of non-smokers or former smokers.
Professor Henry said that their “study showed that when smokers were hospitalized for an acute cardiac event, carbon monoxide levels higher than 13 ppm were associated with poorer outcomes. We also found that carbon monoxide levels was a better predictor of adverse events than smoking status.
He concluded: “The findings suggest that at the time of Measure exhaled carbon monoxide to Assess their prognosis well. “Carbon monoxide poisoning, treated with high-flow oxygen, rapidly reduces dangerous levels in the blood. Further research is needed to determine whether this therapy can improve the outlook after a heart attack in smokers with carbon monoxide levels above 13 ppm.”
quote : Heavy smoking and smoke inhalation may worsen effects of heart attack (26 Aug 2022) Retrieved 4 Sep 2022 from https://medicalxpress.com/news /2022-08-heavy-inhalation-worsen-impact-heart.html
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